The pathogenesis of psoriatic arthritis (PsA) is still under discussion but great advances have been made in the last 2 decades that confirm the central role of tumor necrosis factor-α (TNF-α) in its inflammatory milieu. New therapeutic approaches have been proposed, and new molecules with anti-TNF-α activity have been chemically altered to improve their pharmacological properties. Certolizumab pegol (CZP) is a PEGylated Fc-free anti-TNF that has been shown clinically to be effective in the treatment of rheumatoid arthritis (RA), skin psoriasis, and PsA. This article summarizes available data on its clinical efficacy and safety profile in the treatment of patients with PsA.

New approaches in tumor necrosis factor antagonism for the treatment of psoriatic arthritis: certolizumab pegol

CAULI, ALBERTO;PIGA, MATTEO;FLORIS, ALBERTO;MATHIEU, ALESSANDRO
2015

Abstract

The pathogenesis of psoriatic arthritis (PsA) is still under discussion but great advances have been made in the last 2 decades that confirm the central role of tumor necrosis factor-α (TNF-α) in its inflammatory milieu. New therapeutic approaches have been proposed, and new molecules with anti-TNF-α activity have been chemically altered to improve their pharmacological properties. Certolizumab pegol (CZP) is a PEGylated Fc-free anti-TNF that has been shown clinically to be effective in the treatment of rheumatoid arthritis (RA), skin psoriasis, and PsA. This article summarizes available data on its clinical efficacy and safety profile in the treatment of patients with PsA.
Certolizumab pegol; Psoriatic arthritis; Therapy; Antirheumatic agents; Arthritis, psoriatic; Biological products; Certolizumab pegol; Humans; Treatment outcome; Tumor necrosis factor-alpha; Immunology and allergy; Rheumatology; Immunology; Medicine (all)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11584/185325
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