The novel heteroleptic cyclometalated complex [AuIII(pyb-H)(mnt)] (1; pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate) was tested against a panel of ten Gram positive (belonging to the Staphylococcus, Streptococcus spp. and Bacillus clausii), Gram negative (E. coli, K. pneumoniae, P. aeruginosa) bacteria and three yeasts belonging to the Candida spp. Complex 1 showed a remarkable bacteriostatic antimicrobial activity against staphylococci, with Minimum Inhibitory Concentration (MIC) values of 1.56 and 3.13 μg/mL for S. haemoliticus and S. aureus, respectively. Spectroscopic and electrochemical measurements, supported by Density Functional Theory (DFT) calculations, were exploited to fully investigate the electronic structure of complex 1 and its relationship with the antimicrobial activity

[Au(pyb-H)(mnt)]: A novel gold(III) 1,2-dithiolene cyclometalated complex with antimicrobial activity (pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate)

PINTUS, ANNA
Primo
Membro del Collaboration Group
;
ARAGONI, MARIA CARLA
Membro del Collaboration Group
;
MAIORE, LAURA
Membro del Collaboration Group
;
ISAIA, FRANCESCO
Membro del Collaboration Group
;
LIPPOLIS, VITO
Membro del Collaboration Group
;
ORRU, GERMANO
Membro del Collaboration Group
;
TUVERI, ENRICA
Membro del Collaboration Group
;
ARCA, MASSIMILIANO
Ultimo
Membro del Collaboration Group
2017-01-01

Abstract

The novel heteroleptic cyclometalated complex [AuIII(pyb-H)(mnt)] (1; pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate) was tested against a panel of ten Gram positive (belonging to the Staphylococcus, Streptococcus spp. and Bacillus clausii), Gram negative (E. coli, K. pneumoniae, P. aeruginosa) bacteria and three yeasts belonging to the Candida spp. Complex 1 showed a remarkable bacteriostatic antimicrobial activity against staphylococci, with Minimum Inhibitory Concentration (MIC) values of 1.56 and 3.13 μg/mL for S. haemoliticus and S. aureus, respectively. Spectroscopic and electrochemical measurements, supported by Density Functional Theory (DFT) calculations, were exploited to fully investigate the electronic structure of complex 1 and its relationship with the antimicrobial activity
2017
Gold; Cyclometalation; Dithiolene; Biofilm; Antimicrobic; DFT
File in questo prodotto:
File Dimensione Formato  
JIB_170_188-194_2017.pdf

Solo gestori archivio

Tipologia: versione editoriale (VoR)
Dimensione 917.51 kB
Formato Adobe PDF
917.51 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/214294
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 21
social impact