Chronic inflammation following infections, autoimmune diseases or exposure to environmental irritants plays a crucial role in tumor development and influences the host immune response to neoplastic cells. The presence of an anti-tumor immune infiltrate is often associated with better outcomes in gastro-intestinal primary cancers, particularly in those with high microsatellite instability (MSI-H). Immunotherapeutic drugs inhibiting the PD-1 and PD-L1 pathway showed promising results in the treatment of these patients in the metastatic setting. The aim of this review is to resume the role tumor infiltrating lymphocytes (TILs) play in gastrointestinal tumors, underlining their potential value as a prognostic and predictive biomarker. TILs assessment could identify subsets of patients with high extent of TILs and better prognosis, that could be spared from adjuvant systemic treatments. Immune infiltration parameters might be additional predictors of a greater benefit from the immunotherapy with the immune checkpoint blockade.

Tumor infiltrating lymphocytes in gastrointestinal tumors: Controversies and future clinical implications

PUZZONI, MARCO;SCARTOZZI, MARIO
2017-01-01

Abstract

Chronic inflammation following infections, autoimmune diseases or exposure to environmental irritants plays a crucial role in tumor development and influences the host immune response to neoplastic cells. The presence of an anti-tumor immune infiltrate is often associated with better outcomes in gastro-intestinal primary cancers, particularly in those with high microsatellite instability (MSI-H). Immunotherapeutic drugs inhibiting the PD-1 and PD-L1 pathway showed promising results in the treatment of these patients in the metastatic setting. The aim of this review is to resume the role tumor infiltrating lymphocytes (TILs) play in gastrointestinal tumors, underlining their potential value as a prognostic and predictive biomarker. TILs assessment could identify subsets of patients with high extent of TILs and better prognosis, that could be spared from adjuvant systemic treatments. Immune infiltration parameters might be additional predictors of a greater benefit from the immunotherapy with the immune checkpoint blockade.
2017
Gastrointestinal tumors; Immunotherapy; Microsatellite instability; Prognosis; Tumor infiltrating lymphocytes; Animals; Biomarkers, Tumor; Gastrointestinal Neoplasms; Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Prognosis; Hematology; Oncology; Geriatrics and Gerontology
File in questo prodotto:
File Dimensione Formato  
solinas2016.pdf

Solo gestori archivio

Tipologia: versione post-print
Dimensione 742.61 kB
Formato Adobe PDF
742.61 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/214577
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 31
social impact