To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10^sup -29^ and rs7755224, combined P = 2.00 × 10^sup -19^; r^sup 2^ = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10^sup -9^).

Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

COCCO, PIER LUIGI;
2010

Abstract

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10^sup -29^ and rs7755224, combined P = 2.00 × 10^sup -19^; r^sup 2^ = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10^sup -9^).
Disease susceptibility; Lymphoma, Follicular -- genetics; Genome-Wide Association Study
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/22105
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