Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Conde, L; Halperin, E; Akers, Nk; Brown, Km; Smedby, Ke; Rothman, N; Nieters, A; Slager, Sl; Brooks Wilson, A; Agana, L; Riby, J; Liu, J; Adami, Ho; Darabi, H; Hjalgrim, H; Low, Hq; Humphreys, K; Melbye, M; Chang, Et; Glimelius, B; Cozen, W; Davis, S; Hartge, P; Morton, Lm; Schenk, M; Wang, Ss; Armstrong, B; Kricker, A; Milliken, S; Purdue, Mp; Vajdic, Cm; Boyle, P; Lan, Q; Zahm, Sh; Zhang, Y; Zheng, T; Becker, N; Benavente, Y; Boffetta, P; Brennan, P; Butterbach, K; Cocco, Pier Luigi; Foretova, L; Maynadié, M; De Sanjosé, S; Staines, A; Spinelli, Jj; Achenbach, Sj; Call, Tg; Camp, Nj; Glenn, M; Caporaso, Ne; Cerhan, Jr; Cunningham, Jm; Goldin, Lr; Hanson, Ca; Kay, Ne; Lanasa, Mc; Leis, Jf; Marti, Ge; Rabe, Kg; Rassenti, Lz; Spector, Lg; Strom, Ss; Vachon, Cm; Weinberg, Jb; Holly, Ea; Chanock, S; Smith, Mt; Bracci, Pm; Skibola, Cf

doi:10.1038/ng.626

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10^sup -29^ and rs7755224, combined P = 2.00 × 10^sup -19^; r^sup 2^ = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10^sup -9^).

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Titolo:	Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
Autori:	CONDE L HALPERIN E AKERS NK BROWN KM SMEDBY KE ROTHMAN N NIETERS A SLAGER SL BROOKS WILSON A AGANA L RIBY J LIU J ADAMI HO DARABI H HJALGRIM H LOW HQ HUMPHREYS K MELBYE M CHANG ET GLIMELIUS B COZEN W DAVIS S HARTGE P MORTON LM SCHENK M WANG SS ARMSTRONG B KRICKER A MILLIKEN S PURDUE MP VAJDIC CM BOYLE P LAN Q ZAHM SH ZHANG Y ZHENG T BECKER N BENAVENTE Y BOFFETTA P BRENNAN P BUTTERBACH K COCCO, PIERLUIGI FORETOVA L MAYNADIÉ M DE SANJOSÉ S STAINES A SPINELLI JJ ACHENBACH SJ CALL TG CAMP NJ GLENN M CAPORASO NE CERHAN JR CUNNINGHAM JM GOLDIN LR HANSON CA KAY NE LANASA MC LEIS JF MARTI GE RABE KG RASSENTI LZ SPECTOR LG STROM SS VACHON CM WEINBERG JB HOLLY EA CHANOCK S SMITH MT BRACCI PM SKIBOLA CF mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2010
Rivista:	NATURE GENETICS
Abstract:	To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10^sup -29^ and rs7755224, combined P = 2.00 × 10^sup -19^; r^sup 2^ = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10^sup -9^).
Handle:	http://hdl.handle.net/11584/22105
Tipologia:	1.1 Articolo in rivista

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