Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. The STOP Pain project aimed to evaluate the risk factors that contribute to clinical response and adverse drug reactions to opioids by means of a systematic review and a clinical investigation on paediatric oncological patients.

A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study

Giglio S.
Membro del Collaboration Group
;
2018-01-01

Abstract

Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. The STOP Pain project aimed to evaluate the risk factors that contribute to clinical response and adverse drug reactions to opioids by means of a systematic review and a clinical investigation on paediatric oncological patients.
2018
Cancer pain; Children; Opioid efficacy; Opioid safety; Age factors; Analgesics; Opioid; Biological variation; Population; Cancer pain; Child; Humans; Longitudinal studies; Neoplasms; Pain measurement; Risk factors; Treatment outcome
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/298163
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