This article is focused on the genetic characteristics (HLA-DQ2 and HLA-DQ8) that predispose to a risk for celiac disease. The diagnosis of celiac disease is based on the search for specific serum antibodies and on histological analysis of intestinal biopsies. The genetic test for the detection of HLA-DQ2 and HLA-DQ8 proteins could be used as a preliminary investigation for subjects for which celiac disease is suspected. This would allow to extend the serological and endoscopic analyzes only to genetically predisposed subjects.

Celiac Disease and HLA Molecular Typing

Cannea Faustina Barbara
Writing – Review & Editing
;
Rossino Rossano
Writing – Review & Editing
;
Padiglia Alessandra
Writing – Original Draft Preparation
2022

Abstract

This article is focused on the genetic characteristics (HLA-DQ2 and HLA-DQ8) that predispose to a risk for celiac disease. The diagnosis of celiac disease is based on the search for specific serum antibodies and on histological analysis of intestinal biopsies. The genetic test for the detection of HLA-DQ2 and HLA-DQ8 proteins could be used as a preliminary investigation for subjects for which celiac disease is suspected. This would allow to extend the serological and endoscopic analyzes only to genetically predisposed subjects.
Celiac Disease; Human Leukocyte Antigens; DQ2; DQ8; Gliadin Peptides; Molecular Typing
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/335569
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