Locate full-text(opens in a new window)|View at Publisher| Export | Download | Add to List | More... Epilepsia Volume 55, Issue 6, June 2014, Pages e60-e66 Seizures in fetal alcohol spectrum disorders: Evaluation of clinical, electroencephalographic, and neuroradiologic features in a pediatric case series (Article) Nicita, F.a , Verrotti, A.b, Pruna, D.c, Striano, P.d, Capovilla, G.e, Savasta, S.f, Spartà, M.V.f, Parisi, P.g, Parlapiano, G.h, Tarani, L.h, Spalice, A.a a Child Neurology Division, Department of Pediatrics, Sapienza University of Roma, Viale Regina Elena, Rome-324-00161, Italy b Department of Pediatrics, University of Perugia, Perugia, Italy c Division of Child Neurology and Psychiatry, Azienda University Hospital of Cagliari, Cagliari, Italy View additional affiliations View references (13) Abstract Seizures are observed with a frequency of 3-21% in children with fetal alcohol spectrum disorders (FASD). However, clinical, neuroradiologic, and electroencephalography (EEG) features are poorly described. In this study, 13 patients with FASD and epilepsy or seizures were identified retrospectively from the databases of seven Italian pediatric neurology divisions. Eleven children were affected by epilepsy, and two had at least one documented seizure. Both generalized and focal seizures were observed. EEG showed diffuse or focal epileptic activity; two children developed electric status epilepticus during sleep (ESES). Structural brain anomalies, including polymicrogyria, nodular heterotopia, atrophy, and Arnold-Chiari type 1 malformation, were discovered in almost 50% of patients. Control of seizures was not difficult to obtain in 11 cases; one patient showed pharmacoresistant epilepsy. EEG and clinical follow-up are recommended in children with FASD and epilepsy, since severe conditions requiring aggressive treatment, such as in ESES, may develop. Neuroradiological evaluation is warranted because several types of brain anomalies could be associated with maternal alcohol consumption during pregnancy.
Seizures in fetal alcohol spectrum disorders: Evaluation of clinical, electroencephalographic, and neuroradiologic features in a pediatric case series
Savasta S;
2014-01-01
Abstract
Locate full-text(opens in a new window)|View at Publisher| Export | Download | Add to List | More... Epilepsia Volume 55, Issue 6, June 2014, Pages e60-e66 Seizures in fetal alcohol spectrum disorders: Evaluation of clinical, electroencephalographic, and neuroradiologic features in a pediatric case series (Article) Nicita, F.a , Verrotti, A.b, Pruna, D.c, Striano, P.d, Capovilla, G.e, Savasta, S.f, Spartà, M.V.f, Parisi, P.g, Parlapiano, G.h, Tarani, L.h, Spalice, A.a a Child Neurology Division, Department of Pediatrics, Sapienza University of Roma, Viale Regina Elena, Rome-324-00161, Italy b Department of Pediatrics, University of Perugia, Perugia, Italy c Division of Child Neurology and Psychiatry, Azienda University Hospital of Cagliari, Cagliari, Italy View additional affiliations View references (13) Abstract Seizures are observed with a frequency of 3-21% in children with fetal alcohol spectrum disorders (FASD). However, clinical, neuroradiologic, and electroencephalography (EEG) features are poorly described. In this study, 13 patients with FASD and epilepsy or seizures were identified retrospectively from the databases of seven Italian pediatric neurology divisions. Eleven children were affected by epilepsy, and two had at least one documented seizure. Both generalized and focal seizures were observed. EEG showed diffuse or focal epileptic activity; two children developed electric status epilepticus during sleep (ESES). Structural brain anomalies, including polymicrogyria, nodular heterotopia, atrophy, and Arnold-Chiari type 1 malformation, were discovered in almost 50% of patients. Control of seizures was not difficult to obtain in 11 cases; one patient showed pharmacoresistant epilepsy. EEG and clinical follow-up are recommended in children with FASD and epilepsy, since severe conditions requiring aggressive treatment, such as in ESES, may develop. Neuroradiological evaluation is warranted because several types of brain anomalies could be associated with maternal alcohol consumption during pregnancy.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
