Acute toxicity induced by DMN was partially prevented by previously administering methyl mercuric chloride (MMC), a chemical inhibitor of the drug metabolizing enzyme system (DMES). We have studied the early changes occurring during the course of DMN-intoxication, namely disaggregation of polysomal profiles and necrosis, evaluated morphologically and by the release of S-GPT.

Early investigations on the effect of methyl mercuric chloride upon DMN-acute hepatotoxicity.

COLUMBANO, AMEDEO;
1976-01-01

Abstract

Acute toxicity induced by DMN was partially prevented by previously administering methyl mercuric chloride (MMC), a chemical inhibitor of the drug metabolizing enzyme system (DMES). We have studied the early changes occurring during the course of DMN-intoxication, namely disaggregation of polysomal profiles and necrosis, evaluated morphologically and by the release of S-GPT.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/41263
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