INTRODUCTION: According to IARC, shift work resulting in disruption of circadian rhythm is a probable human carcinogen (Group 2A). METHODS: We examined the scientific literature on the carcinogenic risk among shift workers for risk assessment purposes. RESULTS: Clock genes polymorphisms might contribute with suppression of melatonin synthesis, immuno-suppression from sleep deprivation, individual habits associated with shift work, and low vitamin D levels, in increasing risk of breast cancer, prostate cancer and lymphoma among shift workers. CONCLUSION: Although the epidemiological evidence seems scanty, the hypothesis that shift work-related sleep deprivation would contribute to increasing cancer risk seems based on solid ground.
Cancer risk among shift workers: A review = Rischio oncogeno nei lavoratori a turni: Analisi della letteratura
PULIGHEDDU, MONICA MARIA FRANCESCA;CAMPAGNA, MARCELLO;COCCO, PIER LUIGI;MARROSU, FRANCESCO
2012-01-01
Abstract
INTRODUCTION: According to IARC, shift work resulting in disruption of circadian rhythm is a probable human carcinogen (Group 2A). METHODS: We examined the scientific literature on the carcinogenic risk among shift workers for risk assessment purposes. RESULTS: Clock genes polymorphisms might contribute with suppression of melatonin synthesis, immuno-suppression from sleep deprivation, individual habits associated with shift work, and low vitamin D levels, in increasing risk of breast cancer, prostate cancer and lymphoma among shift workers. CONCLUSION: Although the epidemiological evidence seems scanty, the hypothesis that shift work-related sleep deprivation would contribute to increasing cancer risk seems based on solid ground.File | Dimensione | Formato | |
---|---|---|---|
GIMLE_2013_3_12-14_Atti.pdf
Solo gestori archivio
Tipologia:
versione editoriale
Dimensione
3.41 MB
Formato
Adobe PDF
|
3.41 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.