A self-assembled hybrid phospholipid vesicular system containing various penetration enhancers – ethanol, Transcutol and propylenglycol – was prepared and characterized. The effects of the different alcohol or polyalcohols structure and their concentration on the features of the assembled vesicles were evaluated using a combination of different techniques, including cryo-transmission electron microscopy, laser light scattering, differential scanning calorimetry, small- and wide-angle X-ray scattering and rheological analysis. These techniques allow explaining the structural rearrangements of the bilayer assembly due to the alcohol or polyalcohol addition. X-ray scattering studies showed that such addition at the highest concentration (20%) allowed structure modification to oligolamellar vesicles and a bilayer transition to interdigitated phase. Rheological studies confirmed the importance of alcohol or polyalcohol in the structuring dispersions probably due to a partial tilting of phosphatidylcholine acyl chains forming interdigitated and interconnected bilayer vesicles.

Molecular arrangements and interconnected bilayer formation induced by alcohol or polyalcohol in phospholipid vesicles

MANCA, MARIA LETIZIA;Castangia, I;LAMPIS, SANDRINA;FADDA, ANNA MARIA;MANCONI, MARIA
2014-01-01

Abstract

A self-assembled hybrid phospholipid vesicular system containing various penetration enhancers – ethanol, Transcutol and propylenglycol – was prepared and characterized. The effects of the different alcohol or polyalcohols structure and their concentration on the features of the assembled vesicles were evaluated using a combination of different techniques, including cryo-transmission electron microscopy, laser light scattering, differential scanning calorimetry, small- and wide-angle X-ray scattering and rheological analysis. These techniques allow explaining the structural rearrangements of the bilayer assembly due to the alcohol or polyalcohol addition. X-ray scattering studies showed that such addition at the highest concentration (20%) allowed structure modification to oligolamellar vesicles and a bilayer transition to interdigitated phase. Rheological studies confirmed the importance of alcohol or polyalcohol in the structuring dispersions probably due to a partial tilting of phosphatidylcholine acyl chains forming interdigitated and interconnected bilayer vesicles.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/97607
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