Idiopathic pyoderma gangrenosum: Successful resolution with Infliximab therapy and proinflammatory cytokines assessment

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis of unknown aetiology, characterized by primarily sterile, painful ulcers with typical violaceous undermined borders and mucopurulent or haemorrhagic exudate. PG is commonly associated with other systemic disorders. Diagnosis of primary idiopathic forms is reached following the exclusion of inflammatory bowel disease (IBD), rheumatic disorders, monoclonal gammopathy and solid tumours (1, 2). Treatment is generally based on corticosteroid and immunosuppressive therapy; however, the recent use of biological drugs has shown their effectiveness.