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EnglishA series of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)anilines were synthesized and evaluated in vitro for cytotoxicity and antiviral activity against a large panel of viruses. Most of the tested compounds interfered with RSV replication in the micromolar concentrations (EC50s ranging from 5μM to 28μM). SAR studies suggested that the presence of a trifluoromethyl group in R(1) abolished the anti-RSV activity and enhanced the cytotoxicity while the best results in term of both anti-RSV activity and selectivity were obtained by the introduction in R(1) of a chlorine or a bromine atom.
| Titolo: | N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents |
| Autori: | |
| Data di pubblicazione: | 2015 |
| Rivista: | |
| Citazione: | N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents / Fioravanti, R; Desideri, N; Biava, M; Droghini, P; Atzori, EM; Ibba, C; Collu, G; Sanna, G; Delogu, I; Loddo, R. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 25:11(2015), pp. 2401-2404. |
| Handle: | http://hdl.handle.net/11584/99116 |
| Tipologia: | 1.1 Articolo in rivista |
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| Bioorganic & Medicinal Chemistry Letters 2015.pdf | Versione editoriale | Non specificato | Administrator Richiedi una copia |
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