Differently substituted isonicotinoylhydrazothiazoles and isonicotinoyl-N4-substituted thiosemicarbazides have been prepared and characterized by means of elemental analysis, 1H-NMR, 13C-NMR, and Mass spectrometry. All the synthesised compounds have been screened in order to evaluate their antimycobacterial activity in vitro. Some of the new compounds showed activity towards M. tuberculosis H37R and M. Marinum in the millimolar range.
Isonicotinoylhydrazothiazoles and isonicotinoyl-N-4-substituted thiosemicarbazides: Synthesis, characterization, and anti-mycobacterial activity
CARDIA, MARIA CRISTINA;DISTINTO, SIMONA;MACCIONI, ELIAS;PLUMITALLO, ANTONIO;SANNA, MARIA LUISA;DE LOGU, ALESSANDRO
2006-01-01
Abstract
Differently substituted isonicotinoylhydrazothiazoles and isonicotinoyl-N4-substituted thiosemicarbazides have been prepared and characterized by means of elemental analysis, 1H-NMR, 13C-NMR, and Mass spectrometry. All the synthesised compounds have been screened in order to evaluate their antimycobacterial activity in vitro. Some of the new compounds showed activity towards M. tuberculosis H37R and M. Marinum in the millimolar range.
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