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Anaemia and quality of life in chronic kidney disease: A consensus document from the European Anaemia of CKD Alliance

Anaemia is common in chronic kidney disease (CKD) and has a significant impact on quality of life (QoL), work productivity and outcomes. Current management includes oral or intravenous iron and erythropoiesis-stimulating agents (ESAs), to which hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have been recently added, increasing the available therapeutic options. In randomised controlled trials, only intravenous iron improved cardiovascular outcome, while some ESAs were assoc...

Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV)

In the prevention of epidemic and pandemic emerging and neglected viral infections, natural products are an important source of lead compounds. Hornstedtia bella Škorničkis is a rhizomatous herb growing in the forest of central Vietnam. Hornstedtia bella essential oil (Hb EO) was recently characterised by our group as endowed of antimicrobial activity against Staphylococcus aureus Methicillin-Resistant strains. Here, we describe for the first time the evaluation of Hb EO against a spectrum of...

Spectral analysis of the low-mass X-ray pulsar 4U 1822-371: Reflection component in a high-inclination system

Context. The X-ray source 4U 1822-371 is an eclipsing low-mass X-ray binary and X-ray pulsar, hosting a NS that shows periodic pulsations in the X-ray band with a period of 0.59 s. The inclination angle of the system is so high (80-85°) that in principle, it should be hard to observe both the direct thermal emission of the central object and the reflection component of the spectrum because they are hidden by the outer edge of the accretion disc. Despite the number of studies carried out on th...

C1‐4 Alkylation of Aryl Bromides with Light Alkanes enabled by Metallaphotocatalysis in Flow

The homologous series of gaseous C1-4 alkanes represents one of the most abundant sources of short alkyl fragments. However, their application in synthetic organic chemistry is exceedingly rare due to the challenging C–H bond cleavage, which typically demands high temperatures and pressures, thereby limiting their utility in the construction of complex organic molecules. In particular, the formation of C(sp2 )–C(sp3 ) bonds is crucial for constructing biologically active molecules, i...

Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold

Simultaneous modulation of multifaceted toxicity arising from neuroinflammation, oxidative stress, and mitochondrial dysfunction represents a valuable therapeutic strategy to tackle Alzheimer's disease. Among the significant hallmarks of the disorder, A beta protein and its aggregation products are well-recognised triggers of the neurotoxic cascade. In this study, by tailored modification of the curcumin-based lead compound 1, we aimed at developing a small library of hybrid compounds targeti...

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