Herein, we disclose a general and flexible access to spirocyclopropyl oxindoles by a domino Michael/intramolecular nucleophilic substitution pathway with variously substituted vinyl selenones and enolizable oxindoles in aqueous sodium hydroxide solution. The spirocyclopropyl oxindole being a privileged scaffold, some of the synthesized compounds were selected for biological evaluation. Compound 3m showed selective anti-HIV-1 activity thanks to its ability to inhibit the reverse transcriptase.
|Titolo:||A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity|
|Data di pubblicazione:||2016|
|Tipologia:||1.1 Articolo in rivista|