Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5-40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (McyrillicT-4 cells) and ex vivo (human tonsillar tissue).

5-arylaminouracil derivatives as potential dual-action agents

CORONA, ANGELA;TRAMONTANO, ENZO;
2015

Abstract

Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5-40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (McyrillicT-4 cells) and ex vivo (human tonsillar tissue).
5'-norcarbocyclic nucleoside analogs, 5-(phenylamino)uracil derivatives, Dual action, HIV and Mycobacterium tuberculosis co-infection, Biochemistry, Biotechnology, Molecular biology, Molecular medicine; Virology
File in questo prodotto:
File Dimensione Formato  
Matyugina et al Acta Naturae 2015.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: versione editoriale
Dimensione 107.06 kB
Formato Adobe PDF
107.06 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11584/175741
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact