A ZnO-mediated one-pot solvent-free protocol for the regioselective C-arylsulfonylation of indoles is described and some novel derivatives were tested on wild type and non-nucleoside inhibitor resistant K103N and Y181C HIV-1 reverse transcriptases (RTs).

ZnO-mediated regioselective C-arylsulfonylation of indoles: A facile solvent-free synthesis of 2- and 3-sulfonylindoles and preliminary evaluation of their activity against drug-resistant mutant HIV-1 reverse transcriptases (RTs)

TOCCO, GRAZIELLA;BEGALA, MICHELA;ESPOSITO, FRANCESCA;CABONI, PIERLUIGI;CANNAS, VALERIA;TRAMONTANO, ENZO
2013-01-01

Abstract

A ZnO-mediated one-pot solvent-free protocol for the regioselective C-arylsulfonylation of indoles is described and some novel derivatives were tested on wild type and non-nucleoside inhibitor resistant K103N and Y181C HIV-1 reverse transcriptases (RTs).
2013
Regioselectivity, C-Arylfonylation, Indoles, Non-nucleoside inhibitor, HIV-1 RT
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/56360
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