A ZnO-mediated one-pot solvent-free protocol for the regioselective C-arylsulfonylation of indoles is described and some novel derivatives were tested on wild type and non-nucleoside inhibitor resistant K103N and Y181C HIV-1 reverse transcriptases (RTs).
ZnO-mediated regioselective C-arylsulfonylation of indoles: A facile solvent-free synthesis of 2- and 3-sulfonylindoles and preliminary evaluation of their activity against drug-resistant mutant HIV-1 reverse transcriptases (RTs)
TOCCO, GRAZIELLA;BEGALA, MICHELA;ESPOSITO, FRANCESCA;CABONI, PIERLUIGI;CANNAS, VALERIA;TRAMONTANO, ENZO
2013-01-01
Abstract
A ZnO-mediated one-pot solvent-free protocol for the regioselective C-arylsulfonylation of indoles is described and some novel derivatives were tested on wild type and non-nucleoside inhibitor resistant K103N and Y181C HIV-1 reverse transcriptases (RTs).File in questo prodotto:
File | Dimensione | Formato | |
---|---|---|---|
Tocco et al TETRAHEDRON LETTERS 2013.pdf
Solo gestori archivio
Tipologia:
versione pre-print
Dimensione
157.16 kB
Formato
Adobe PDF
|
157.16 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.